General Information

  • ID:  hor000291
  • Uniprot ID:  P84825
  • Protein name:  Bradykinin
  • Gene name:  NA
  • Organism:  Ascaphus truei (Coastal tailed frog)
  • Family:  Bradykinin-related peptide family
  • Source:  animal
  • Expression:  Expressed by the skin glands.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Ascaphus (genus), Ascaphidae (family), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0003674 molecular_function; GO:0090729 toxin activity
  • GO BP:  GO:0006952 defense response; GO:0035821 modulation of process of another organism; GO:0042311 vasodilation; GO:0097746 blood vessel diameter maintenance
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  RPPGFSPFR
  • Length:  9
  • Propeptide:  RPPGFSPFR
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Induces relaxation of mouse trachea that has been precontracted with methacholine. May induce relaxation of arterial smooth muscle
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: 29±1 minutes; /1740 seconds ( PubMed ID: 8395230 )

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P56388-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P56388-F1.pdbhor000291_AF2.pdbhor000291_ESM.pdb

Physical Information

Mass: 120307 Formula: C50H73N15O11
Absent amino acids: ACDEHIKLMNQTVWY Common amino acids: P
pI: 12.5 Basic residues: 2
Polar residues: 2 Hydrophobic residues: 2
Hydrophobicity: -104.44 Boman Index: -2634
Half-Life: 1 hour Half-Life Yeast: 2 min
Half-Life E.Coli: 2 min Aliphatic Index 0
Instability Index: 12191.11 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  15922344##8395230
  • Title:  Bradykinin-related Peptides and Tryptophyllins in the Skin Secretions of the Most Primitive Extant Frog, Ascaphus Truei